The company forecasts a 20% increase in the average number of cars being driven on Thursday (13 April) and Easter Monday.
Thursday is set to be the busiest day of the Easter period as drivers set off early to enjoy the full weekend, meaning peaks will reach 28.4% above average traffic levels at 5pm on Thursday.
The major motorways are expected to be the worst affected roads on Thursday, with predictions that journeys will take as much as three times longer than on an average evening.
Inrix suggests motorists driving on Thursday avoid using major roads between 4pm and 6pm in order to try and avoid the worst of the delays. It also recommends avoiding travelling at this time if possible.
Those driving between junctions 9 and 21 on the M25, in both directions, and those travelling on the M6 in both directions and the M5 southbound to the West Country will see some of the worst traffic.
Sunday is set to be the quietest day of the whole weekend, with Inrix's data suggesting there will be 25% fewer vehicles on the roads when compared to an average Sunday.
Chief economist and head of research at Inrix, Graham Cookson, warned: "We expect significant delays over the Easter period due to a combination of factors, including the regular post-work peak, the start of the school break, people travelling on holiday, railway engineering works and tube closures.
"Our advice to drivers is to consider alternative routes or avoid peak times altogether. By checking live traffic data drivers can ensure they reach their destinations in good time."